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    Title: An Alternative Synthesis of 3′,4′-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae
    Authors: Shih, Tzenge-Lien;Hsiao, Chih-Ang;Lin, Zi-Yu;Chen, Yau-Hung
    Contributors: 淡江大學化學學系
    Keywords: antioxidant;Baker-Venkataraman;rearrangement;diaminoflavones;ROS-scavenging;zebrafish larvae
    Date: 2012-07
    Issue Date: 2013-01-08 13:07:13 (UTC+8)
    Publisher: Basel: M D P I AG
    Abstract: We described herein a concise synthesis of 3′,4′-diaminoflavone 10. This new, three-step synthetic approach is more efficient than the conventional seven-step synthetic method. The route is shortened significantly by introducing the amino moieties early and eliminating the need for nitro group reduction. The other two analogues, 5,7-dihydroxy-3′,4′-diaminoflavone 11 and 5,7-dimethoxy-3′,4′-diaminoflavone 12, were also synthesized similarly. The above three compounds, along with flavone, were evaluated for their antioxidant and UVB-protection abilities on zebrafish larvae. The data showed that compound 10 exhibited the best result, with −102.3% of ROS-scavenging rate.
    Relation: Molecules 17(7), pp.8206-8216
    DOI: 10.3390/molecules17078206
    Appears in Collections:[化學學系暨研究所] 期刊論文

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