English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 49523/84737 (58%)
造訪人次 : 7605946      線上人數 : 54
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/79662


    題名: Cardiac Myosin Binding Protein C and MAP-Kinase Activating Death Domain-Containing Gene Polymorphisms and Diastolic Heart Failure
    作者: Wu, Cho-Kai;Huang, Yin-Tsen;Lee, Jen-Kuang;Chiang, Liang-Ting;Chiang, Fu-Tien;Huang, Shu-Wei;Lin, Jiunn-Lee;Tseng, Chuen-Den;Chen, Yau-Hung;Tsai, Chia-Ti
    貢獻者: 淡江大學化學學系
    關鍵詞: GENETIC polymorphisms;MUSCLE proteins;VITAMIN K-dependent proteins;POLYMORPHISM (Zoology);BLOOD coagulation factors;CIRCULATING anticoagulants;CARRIER proteins
    日期: 2012-04
    上傳時間: 2013-01-08 12:57:41 (UTC+8)
    出版者: San Francisco: Public Library of Science
    摘要: Objective: Myosin binding protein C (MYBPC3) plays a role in ventricular relaxation. The aim of the study was to investigate the association between cardiac myosin binding protein C (MYBPC3) gene polymorphisms and diastolic heart failure (DHF) in a human case-control study.
    Methods: A total of 352 participants of 1752 consecutive patients from the National Taiwan University Hospital and its affiliated hospital were enrolled. 176 patients diagnosed with DHF confirmed by echocardiography were recruited. Controls were matched 1-to-1 by age, sex, hypertension, diabetes, renal function and medication use. We genotyped 12 single nucleotide polymorphisms (SNPs) according to HapMap Han Chinese Beijing databank across a 40 kb genetic region containing the MYBPC3 gene and the neighboring DNA sequences to capture 100% of haplotype variance in all SNPs with minor allele frequencies ≥5%. We also analyzed associations of these tagging SNPs and haplotypes with DHF and linkage disequilibrium (LD) structure of the MYBPC3 gene.
    Results: In a single locus analysis, SNP rs2290149 was associated with DHF (allele-specific p = 0.004; permuted p = 0.031). The SNP with a minor allele frequency of 9.4%, had an odds ratio 2.14 (95% CI 1.25-3.66; p = 0.004) for the additive model and 2.06 for the autosomal dominant model (GG+GA : AA, 95% CI 1.17-3.63; p = 0.013), corresponding to a population attributable risk fraction of 12.02%. The haplotypes in a LD block of rs2290149 (C-C-G-C) was also significantly associated with DHF (odds ratio 2.10 (1.53-2.89); permuted p = 0.029). Conclusions: We identified a SNP (rs2290149) among the tagging SNP set that was significantly associated with early DHF in a Chinese population.
    關聯: PLoS ONE 7(4), pp.1-6
    DOI: 10.1371/journal.pone.0035242
    顯示於類別:[化學學系暨研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    2012 PLoS One.pdf1069KbAdobe PDF320檢視/開啟
    index.html0KbHTML218檢視/開啟

    在機構典藏中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋