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    題名: Caffeine treatment disturbs the angiogenesis of zebrafish embryos
    作者: Yeh, Chien-Hung;Liao, Yun-Feng;Chang, Chao-Yuan;Tsai, Jen-Ning;Wang, Yun-Hsin;Cheng, Chien-Chung;Wen, Chi-Chung;Chen, Yau-Hung
    貢獻者: 淡江大學生命科學研究所;淡江大學化學學系
    關鍵詞: Angiogenesis;caffeine;fluorescent protein;transgenic fish;zebrafish
    日期: 2012-10
    上傳時間: 2013-01-08 12:47:59 (UTC+8)
    出版者: New York: Informa Healthcare
    摘要: Caffeine is a widely consumed substance that occurs in numerous dietary sources, but teratogenic effects of caffeine intake during embryonic development are still not clear. In the present study, we used the zebrafish as a model to assess caffeine-induced toxicity on embryonic vascular development. A green fluorescent vascular endothelium transgenic line, Tg(fli1:egfp), was utilized for the sensitive detection of vascular development, including vasculo- and angiogenesis. Caffeine-treated embryos showed no defects in vasculogenesis, but revealed dose-dependent (250-350 ppm) developmental defects in intersegmental vessels, dorsal longitudinal anastomotic vessels, and subintestinal vein sprouting. Further, real-time polymerase chain reaction analysis of caffeine-treated embryos showed an upregulation of nrp1a along with a downregulation of sema3aa and sema3c. In conclusion, caffeine treatment induces defects of angiogenesis in zebrafish embryos.
    關聯: Drug and Chemical Toxicology 35(4), pp.361-365
    DOI: 10.3109/01480545.2011.627864
    顯示於類別:[生命科學研究所] 期刊論文
    [化學學系暨研究所] 期刊論文

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