Flavone is efficient to protect zebrafish fins from UV-induced damages

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Title:	Flavone is efficient to protect zebrafish fins from UV-induced damages
Authors:	Tsai, I-Ting;Yang, Zhi-Shiang;Lin, Zi-Yu;Wen, Chi-Chung;Cheng, Chien-Chung;Chen, Yau-Hung
Contributors:	淡江大學數學學系;淡江大學化學學系
Keywords:	Chalcone;fin;flavone;UV;xebrafish
Date:	2012-01-31
Issue Date:	2013-01-08 12:45:05 (UTC+8)
Abstract:	We used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids.
Relation:	Drug and Chemical Toxicology 35(3), p.341-346
DOI:	10.3109/01480545.2011.622771
Appears in Collections:	[Graduate Institute & Department of Mathematics] Journal Article [Graduate Institute & Department of Chemistry] Journal Article

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