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    題名: Flavone is efficient to protect zebrafish fins from UV-induced damages
    作者: Tsai, I-Ting;Yang, Zhi-Shiang;Lin, Zi-Yu;Wen, Chi-Chung;Cheng, Chien-Chung;Chen, Yau-Hung
    貢獻者: 淡江大學數學學系;淡江大學化學學系
    關鍵詞: Chalcone;fin;flavone;UV;zebrafish
    日期: 2012-07
    上傳時間: 2013-01-08 12:45:05 (UTC+8)
    摘要: We used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids.
    關聯: Drug and Chemical Toxicology 35(3), pp.341-346.
    DOI: 10.3109/01480545.2011.622771
    顯示於類別:[化學學系暨研究所] 期刊論文
    [數學學系暨研究所] 期刊論文

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