淡江大學機構典藏:Item 987654321/79026
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 62805/95882 (66%)
造访人次 : 3945599      在线人数 : 578
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/79026


    题名: Protective effects of myricetin against ultraviolet-B-induced damage in human keratinocytes
    作者: Huang, Jheng-Hua;Huang, Chieh-Chen;Fang, Jia-You;Yang, Cheng;Chan, Chi-Ming;Wu, Nan-Lin;Kang, Shung-Wen;Hung, Chi-Feng
    贡献者: 淡江大學機械與機電工程學系
    关键词: Keratinocyte;Myricetin;UVB
    日期: 2010-02
    上传时间: 2012-11-21 15:24:31 (UTC+8)
    出版者: Kidlington: Pergamon
    摘要: Myricetin is a flavonoid similar to quercetin, which is commonly found in natural foods such as berries, vegetables, teas, wine, and herbs. It is considered to be an antioxidant which is capable of quenching photoaging-causing free radicals within the skin. In this study, we investigated the mechanisms underlying protective effect of myricetin on ultraviolet-B (UVB)-induced damage to keratinocytes. We found that myricetin concentration-dependently attenuated UVB-induced keratinocyte death as determined by a cell viability assay. Pretreatment with myricetin also reduced the UVB-induced malondialdehyde level. Moreover, UVB-induced H2O2 generation in keratinocytes was inhibited by myricetin according to flow cytometry, suggesting that myricetin can act as a free radical scavenger when keratinocytes experience photodamage. Furthermore, UVB-induced activation of c-jun-NH2 terminal kinase (JNK) in keratinocytes was inhibited by myricetin. UVB-induced pre-G1 phase arrest leading to apoptotic changes in keratinocytes was blocked by myricetin. Taken together, the protective mechanisms of keratinocyte by myricetin against UVB-induced photodamage occur by the inhibition of UVB-induced intracellular hydrogen peroxide production, lipid peroxidation and JNK activation. Therefore, myricetin is suitable for further development as an anti-aging agent for skin care.
    關聯: Toxicology in Vitro 24(1), pp.21-28
    DOI: 10.1016/j.tiv.2009.09.015
    显示于类别:[機械與機電工程學系暨研究所] 期刊論文

    文件中的档案:

    档案 大小格式浏览次数
    index.html0KbHTML241检视/开启

    在機構典藏中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈