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    Title: Protective effects of myricetin against ultraviolet-B-induced damage in human keratinocytes
    Authors: Huang, Jheng-Hua;Huang, Chieh-Chen;Fang, Jia-You;Yang, Cheng;Chan, Chi-Ming;Wu, Nan-Lin;Kang, Shung-Wen;Hung, Chi-Feng
    Contributors: 淡江大學機械與機電工程學系
    Keywords: Keratinocyte;Myricetin;UVB
    Date: 2010-02
    Issue Date: 2012-11-21 15:24:31 (UTC+8)
    Publisher: Kidlington: Pergamon
    Abstract: Myricetin is a flavonoid similar to quercetin, which is commonly found in natural foods such as berries, vegetables, teas, wine, and herbs. It is considered to be an antioxidant which is capable of quenching photoaging-causing free radicals within the skin. In this study, we investigated the mechanisms underlying protective effect of myricetin on ultraviolet-B (UVB)-induced damage to keratinocytes. We found that myricetin concentration-dependently attenuated UVB-induced keratinocyte death as determined by a cell viability assay. Pretreatment with myricetin also reduced the UVB-induced malondialdehyde level. Moreover, UVB-induced H2O2 generation in keratinocytes was inhibited by myricetin according to flow cytometry, suggesting that myricetin can act as a free radical scavenger when keratinocytes experience photodamage. Furthermore, UVB-induced activation of c-jun-NH2 terminal kinase (JNK) in keratinocytes was inhibited by myricetin. UVB-induced pre-G1 phase arrest leading to apoptotic changes in keratinocytes was blocked by myricetin. Taken together, the protective mechanisms of keratinocyte by myricetin against UVB-induced photodamage occur by the inhibition of UVB-induced intracellular hydrogen peroxide production, lipid peroxidation and JNK activation. Therefore, myricetin is suitable for further development as an anti-aging agent for skin care.
    Relation: Toxicology in Vitro 24(1), pp.21-28
    DOI: 10.1016/j.tiv.2009.09.015
    Appears in Collections:[機械與機電工程學系暨研究所] 期刊論文

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