This paper investigated the structural responses of the wind turbine due to wind loads by performing the wind tunnel test and the Computational Fluid Dynamics, (CFD). The base shear force and the base moment of the wind turbine measured by the wind tunnel test were compared with the numerical simulation results. Both the numerical dynamic mesh and sliding mesh models were selected for the numerical simulations. The results showed that the dynamic mesh model was better than the sliding model by comparing to the wind tunnel test result. In the case of the k-epsilon RNG turbulence model, the prediction of the bending moment affecting by acrossswind was more than 50%, and the prediction of the force affecting by acrosswind was less than 3%. The both simulation results of the prototype and the full scale wind turbine were obtained by CFD model. The comparisons of the result showed that the error of Fx was about 15% and My was about 13.5%.