Effect of Renal Impairment on Mortality of Patients With Cirrhosis and Spontaneous Bacterial Peritonitis

doi:10.1016/j.cgh.2012.02.026

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Title:	Effect of Renal Impairment on Mortality of Patients With Cirrhosis and Spontaneous Bacterial Peritonitis
Authors:	Hung, Tsung–hsing;Tsai, Chen–chi;Hsieh, Yu–hsi;Tsai, Chih–chun;Tseng, Chih–wei;Tsai, Jai–jen
Contributors:	淡江大學數學學系
Keywords:	Dialysis;Prognosis;Risk Factor;Liver Disease
Date:	2012-06-01
Issue Date:	2012-10-02 20:09:44 (UTC+8)
Publisher:	Maryland Heights: W.B. Saunders Co.
Abstract:	BACKGROUND & AIMS:The effects of end-stage renal disease (ESRD) on the mortality of patients with cirrhosis and spontaneous bacterial peritonitis (SBP) have not been determined. METHODS:We collected data from Taiwan's National Health Insurance Database on 2592 patients with cirrhosis who were hospitalized with SBP from January 1 to December 31, 2004. Patients were matched with individuals from a national mortality database; 30-day and 1-year mortalities were calculated for each group and compared to calculate hazard ratios (HRs). RESULTS:Of the patients with cirrhosis and SBP, 300 (11.5%) had renal function impairment. Of these, 145 had acute renal failure, 70 had ESRD, and 75 had chronic kidney disease. Overall, 30-day and 1-year mortality were 21.3% and 51.7%, respectively. After adjusting for age, sex, and underlying comorbidities, HRs for 30-day mortality from renal function impairment, acute renal failure, ESRD, and chronic kidney disease were 3.00, 4.68, 1.93, and 1.37, respectively. The HRs for 1-year mortality from renal function impairment, acute renal failure, ESRD, and chronic kidney disease were 2.03, 2.78, 1.70, and 1.37, respectively. The adjusted HRs for 30-day and 1-year mortality of patients with acute renal failure were 2.6 and 1.6, respectively, compared with patients with ESRD. CONCLUSIONS:Acute renal failure is a better determinant of 30-day and 1-year mortality than renal function impairment in cirrhotic patients with SBP.
Relation:	Clinical Gastroenterology and Hepatology 10(6), pp.677-681
DOI:	10.1016/j.cgh.2012.02.026
Appears in Collections:	[Graduate Institute & Department of Mathematics] Journal Article

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