使用銅催化不同取代基的鄰溴苯基乙腈合成多種螺-吲哚酮衍伸物的方法被開發出來，此方法是有效率的，且起始物為便宜以及方便被利用的符合經濟效益。此方經由Domino-Ullmann-type交互耦合反應法可以容易的建構螺-吲哚酮結構，且反應條件溫和。最後我們使用此方法合成天然物生物鹼(±)-coerulescine和(±)-horsfiline並且有好的總產率。 An efficient copper-catalyzed approach to spiro-oxindoles derivatives has been developed, and the protocol uses cheap and readily available substituted 2-bromophenylacetonitrile as the starting materials as well as economical. This method can be easy for constructing spiro-oxindoles via Domino-Ullmann-type coupling under mild conditions. Finally, we synthesized natural products of the oxindole alkaloids (±)-coerulescine and (±)-horsfiline by this method in excellent overall yields.
