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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/77371

    Title: 利用銅催化溴苯乙腈衍生物合成螺-吲哚酮化合物
    Other Titles: Cu(i)-catalyzed synthesis of spiro-oxindoles from 2-bromophenylacetonitrile derivatives
    Authors: 傅軍豪;Fu, Jun-Hao
    Contributors: 淡江大學化學學系碩士班
    謝仁傑;Hsieh, Jen-Chieh
    Keywords: 烏爾曼反應;串聯反應;螺-吲哚酮;Ullmann Reaction;Domino Reaction;spiro-oxindoles
    Date: 2012
    Issue Date: 2012-06-21 06:37:56 (UTC+8)
    Abstract: 使用銅催化不同取代基的鄰溴苯基乙腈合成多種螺-吲哚酮衍伸物的方法被開發出來,此方法是有效率的,且起始物為便宜以及方便被利用的符合經濟效益。此方經由Domino-Ullmann-type交互耦合反應法可以容易的建構螺-吲哚酮結構,且反應條件溫和。最後我們使用此方法合成天然物生物鹼(±)-coerulescine和(±)-horsfiline並且有好的總產率。
    An efficient copper-catalyzed approach to spiro-oxindoles derivatives has been developed, and the protocol uses cheap and readily available substituted 2-bromophenylacetonitrile as the starting materials as well as economical. This method can be easy for constructing spiro-oxindoles via Domino-Ullmann-type coupling under mild conditions. Finally, we synthesized natural products of the oxindole alkaloids (±)-coerulescine and (±)-horsfiline by this method in excellent overall yields.
    Appears in Collections:[Graduate Institute & Department of Chemistry] Thesis

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