English  |  正體中文  |  简体中文  |  Items with full text/Total items : 49942/85109 (59%)
Visitors : 7785672      Online Users : 55
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/76971


    Title: Fin reduction is a novel and unexpected teratogenic effect of amikacin-treated zebrafish embryos
    Authors: Chen, Ying-Hsin;Tsai, I-Ting;Wen, Chi-Chung;Wang, Yun-Hsin;Cheng, Chien-Chung;Hu, Sheng-Chuan;Chen, Yau-Hung
    Contributors: 淡江大學數學學系;淡江大學化學學系
    Keywords: Amikacin;fin;zebrafish;ototoxicity;neuromast
    Date: 2012-02
    Issue Date: 2012-05-23 12:12:11 (UTC+8)
    Publisher: New York: Informa Healthcare
    Abstract: We used zebrafish as a model to assess amikacin-induced embryotoxicity. We exposed zebrafish embryos to amikacin, using different amikacin doses (0-10 ppm), durations (12-48 h), and onsets (0, 24, 48 hpf). Amikacin-induced embryonic toxicity and reduced survival rate were found dependent on the exposure dose, duration and onset. Based on immunostaining with neuron-specific antibodies, amikacin reduced the number and size of zebrafish neuromasts. In addition, Amikacin caused pelvic, dorsal and anal fin defects in dose-dependent and duration-dependent manners. Proliferating cell nuclear antigen immunostaining revealed that amikacin-induced fin defects were not due to reduction of proliferating mesenchymal cells. TUNEL assay demonstrated that amikacin-induced fin defects might not associate with apoptosis. Therefore, further investigations are required to elucidate if other cell death pathways are involved in amikacin-induced fin defects.
    Relation: Toxicology Mechanisms and Methods 22(2), pp.151-158
    DOI: 10.3109/15376516.2011.610385
    Appears in Collections:[數學學系暨研究所] 期刊論文

    Files in This Item:

    File Description SizeFormat
    2012 TMAM.pdf1140KbAdobe PDF587View/Open
    index.html0KbHTML63View/Open

    All items in 機構典藏 are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback