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    题名: Fin reduction is a novel and unexpected teratogenic effect of amikacin-treated zebrafish embryos
    作者: Chen, Ying-Hsin;Tsai, I-Ting;Wen, Chi-Chung;Wang, Yun-Hsin;Cheng, Chien-Chung;Hu, Sheng-Chuan;Chen, Yau-Hung
    贡献者: 淡江大學數學學系;淡江大學化學學系
    关键词: Amikacin;fin;zebrafish;ototoxicity;neuromast
    日期: 2012-02
    上传时间: 2012-05-23 12:12:11 (UTC+8)
    出版者: New York: Informa Healthcare
    摘要: We used zebrafish as a model to assess amikacin-induced embryotoxicity. We exposed zebrafish embryos to amikacin, using different amikacin doses (0-10 ppm), durations (12-48 h), and onsets (0, 24, 48 hpf). Amikacin-induced embryonic toxicity and reduced survival rate were found dependent on the exposure dose, duration and onset. Based on immunostaining with neuron-specific antibodies, amikacin reduced the number and size of zebrafish neuromasts. In addition, Amikacin caused pelvic, dorsal and anal fin defects in dose-dependent and duration-dependent manners. Proliferating cell nuclear antigen immunostaining revealed that amikacin-induced fin defects were not due to reduction of proliferating mesenchymal cells. TUNEL assay demonstrated that amikacin-induced fin defects might not associate with apoptosis. Therefore, further investigations are required to elucidate if other cell death pathways are involved in amikacin-induced fin defects.
    關聯: Toxicology Mechanisms and Methods 22(2), pp.151-158
    DOI: 10.3109/15376516.2011.610385
    显示于类别:[數學學系暨研究所] 期刊論文

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