English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 49287/83828 (59%)
造訪人次 : 7148234      線上人數 : 90
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/75805


    題名: A Comprehensive System for Identifying Internal Repeat Substructures of Proteins
    作者: Kao, Hua-ying;Shih, Tsang-huang;Pai, Tun-wen;Lu, Ming-da;Hsu, Hui-huang
    貢獻者: 淡江大學資訊工程學系
    關鍵詞: Length Encoded Secondary Structure;internal repeat unit;secondary structure element;sequence alignment;solenoid;structure alignment
    日期: 2010-02
    上傳時間: 2012-04-16 09:50:10 (UTC+8)
    出版者: IEEE Computer Society
    摘要: Repetitive substructures within a protein play an important role in understanding protein folding and stability, biological function, and genome evolution. About 25% of all proteins contain repeat structures for eukaryote species and most of them do not have the resolved structural information yet. Therefore, this study aimed to design a comprehensive system for identifying internal repeats either from a protein sequence or structural information. In this study, we have curated a set of internal repeat units as a benchmark dataset for performing both sequence and structural alignment with respect to the query sequence or structure. Except for the traditional BLAST algorithms on amino acid sequence or the optimal structural superposition approaches on structures, a novel method employing the predicted secondary structure element information for internal repeat identification was proposed. Sequences were firstly transformed into Length Encoded Secondary Structure (LESS) profiles and followed by autocorrelation analyses. From the primary experimental results, the developed Internal Repeat Identification System (IRIS) can successfully identify internal repeats from those known protein structures, and the web system is freely available at http://iris.cs.ntou.edu.tw/.
    關聯: Proceedings of the Fourth International Conference on Complex, Intelligent and Software Intensive Systems (CISIS 2010), pp.689-693
    DOI: 10.1109/CISIS.2010.92
    顯示於類別:[資訊工程學系暨研究所] 會議論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    A comprehensive system for identifying internal repeat.pdf全文檔446KbAdobe PDF164檢視/開啟
    index.html0KbHTML155檢視/開啟

    在機構典藏中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋