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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/75752

    Title: Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy
    Authors: Chuang,Tzu-Chao;Liu,Jah-Yao;Lin,Chi-Tsai;Tang,Ya-Ting;Yeh,Ming-Han;Chang, Su-Chien;Li,Jhy-Wei;Kao,Ming-Ching
    Contributors: 淡江大學化學學系
    Keywords: HER2/neu;MnSOD;Metastasis;Breast cancers
    Date: 2007-09-18
    Issue Date: 2012-04-12 11:51:57 (UTC+8)
    Publisher: Amsterdam: Elsevier BV
    Abstract: The up-regulation of HER2/neu is associated with human malignancies and is a useful target for developing anticancer drugs. Overexpression of human manganese superoxide dismutase (MnSOD) has been demonstrated to effectively suppress various carcinoma cells, including breast carcinomas, in vitro and in vivo. This study demonstrates that MnSOD effectively suppresses HER2/neu oncogene expression at the transcriptional level. Additionally, stable transfection was used and the MnSOD-transfected human breast cancer clones were found to be able to down-regulate the endogenous production of p185HER2/neu. Furthermore, the MnSOD-overexpressing stable transfectants exhibited reduced soft-agarose colony-forming ability and metastatic properties, unlike control cell lines. These data suggest that MnSOD may be useful in treating HER2/neu-mediated human breast tumor malignancy.
    Relation: FEBS Letters 581(23), pp.4443-4449
    DOI: 10.1016/j.febslet.2007.08.021
    Appears in Collections:[化學學系暨研究所] 期刊論文

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