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    題名: Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy
    作者: Chuang,Tzu-Chao;Liu,Jah-Yao;Lin,Chi-Tsai;Tang,Ya-Ting;Yeh,Ming-Han;Chang, Su-Chien;Li,Jhy-Wei;Kao,Ming-Ching
    貢獻者: 淡江大學化學學系
    關鍵詞: HER2/neu;MnSOD;Metastasis;Breast cancers
    日期: 2007-09-18
    上傳時間: 2012-04-12 11:51:57 (UTC+8)
    出版者: Amsterdam: Elsevier BV
    摘要: The up-regulation of HER2/neu is associated with human malignancies and is a useful target for developing anticancer drugs. Overexpression of human manganese superoxide dismutase (MnSOD) has been demonstrated to effectively suppress various carcinoma cells, including breast carcinomas, in vitro and in vivo. This study demonstrates that MnSOD effectively suppresses HER2/neu oncogene expression at the transcriptional level. Additionally, stable transfection was used and the MnSOD-transfected human breast cancer clones were found to be able to down-regulate the endogenous production of p185HER2/neu. Furthermore, the MnSOD-overexpressing stable transfectants exhibited reduced soft-agarose colony-forming ability and metastatic properties, unlike control cell lines. These data suggest that MnSOD may be useful in treating HER2/neu-mediated human breast tumor malignancy.
    關聯: FEBS Letters 581(23), pp.4443-4449
    DOI: 10.1016/j.febslet.2007.08.021
    顯示於類別:[化學學系暨研究所] 期刊論文


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