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    題名: Calcium phosphates synthesized by reverse emulsion method for the preparation of chitosan composite membranes
    作者: Tai, Hung-Yin;Fu, Earl;Don, Trong-Ming
    貢獻者: 淡江大學化學工程與材料工程學系
    關鍵詞: Chitosan;Calcium phosphate;Composite membranes
    日期: 2012-04-15
    上傳時間: 2012-03-13 10:26:21 (UTC+8)
    出版者: Pergamon: Pergamon
    摘要: Calcium deficient hydroxyapatite (CDHA) having an average particle size of 45 nm was synthesized by reverse emulsion method. It was converted to the respective biphasic calcium phosphate (BCP, 226 nm) and β-tricalcium phosphate (TCP, 450 nm) by calcination at 800 °C and 1000 °C, and the BCP consisted of 92% TCP and 8% CDHA. Subsequently, chitosan was mixed with calcium phosphates to prepare CDHA/chitosan, BCP/chitosan, and TCP/chitosan membranes. The initial moduli of the BCP/chitosan and TCP/chitosan membranes were about 1.9 times that of the pure chitosan membrane; and the elongations at break were almost 6 times. The CDHA/chitosan and BCP/chitosan could induce mineralization of apatite on the membranes by increasing 20.6 and 16.3 wt.%, respectively, after 24 days in the simulated body fluid. Moreover, the BCP/chitosan exhibited superior osteoblast cell attachment and proliferation than the other membranes. It has the potential to be used as the barrier membrane for guided bone regeneration.
    關聯: Carbohydrate Polymers 88(3), pp.904–911
    DOI: 10.1016/j.carbpol.2012.01.042
    顯示於類別:[化學工程與材料工程學系暨研究所] 期刊論文

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