3,3'-二吲哚甲烷藉由降低HER2neu誘使HER2/neu過表現卵巢癌和乳癌細胞凋亡

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Title:	3,3'-二吲哚甲烷藉由降低HER2neu誘使HER2/neu過表現卵巢癌和乳癌細胞凋亡
Other Titles:	3, 3’-diindolylmethane induces apoptosis through reduction of HER2/neu in HER2/neu-overexpressing ovarian and breast cancers
Authors:	梁展帆;Liang, Chan-Fan
Contributors:	淡江大學化學學系碩士班莊子超
Keywords:	神經膠原致癌基因;3, 3'-二吲哚甲烷;HER2/neu;3,3'-diindolylmethe
Date:	2011
Issue Date:	2011-12-28 18:07:06 (UTC+8)
Abstract:	致癌基因 HER2/neu 過表現導致腫瘤細胞侵入、轉移和血管新生。文獻指出， 3,3’-二吲哚甲烷 (3,3’-diindolylmethane, DIM) 擁有抗癌活性。本實驗證實 DIM 能夠抑制 HER2/neu 表現的卵巢癌和乳癌細胞增生。本實驗結果顯示 DIM 在 HER2/neu 表現的卵巢癌和乳癌細胞中，能抑制 HER2/neu 和其下游 PI3K/Akt 訊號傳遞路徑，因此降低 HER2/neu 誘導的腫瘤轉移能力。此外從 PARP 被切斷的程度顯示 DIM 能促進卵巢癌和乳癌細胞凋亡。總和以上結果，本實驗為 DIM 的抗癌效應提出新的分子機制。 Overexpression of the HER2 oncogene contributes to tumor cell invasion, metastasis and angiogenesis. 3,3’-diindolylmethane (DIM) has been reported to exhibit anti-tumor activities. Here, we examined the anti-proliferating effects of DIM on HER2-positive ovarian and breast cancer cells. Our results demonstrated that DIM may inhibit HER2 and its downstream PI3K/Akt-signaling network, thus resulting in suppression of HER2-mediated metastatic potential in HER2-positive ovarian and breast cancers. Besides, DIM-induced apoptosis in HER2-positive ovarian and breast cancer cells was characterized by the up-regulation of cleaved poly(ADP-ribose) polymerase (PARP). Taken together, our data provide a new mechanism for the DIM-mediated anticancer effect.
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