攪拌透析過濾玻尿酸溶液濾速行為之研究

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Title:	攪拌透析過濾玻尿酸溶液濾速行為之研究
Other Titles:	Flux Behavior of Hyaluronic Acid Solution in Stirred Diafiltration
Authors:	鄭東文;Cheng, Tung-wen;許哲榮;Hsu, C.J.
Contributors:	淡江大學化學工程與材料工程學系
Keywords:	透析過濾;玻尿酸;攪拌槽;濃度極化;Diafiltration;Hyaluronic acid;Stirred cell;Concentration polarization
Date:	2008
Issue Date:	2012-12-03 23:30:15 (UTC+8)
Publisher:	臺北市：行政院國家科學委員會
Abstract:	本研究以恆壓過濾系統，採透析過濾及濃縮程序兩種操作方法過濾玻尿酸溶液，操作參數包括有pH值 (3 、5 、7 、13) 、rpm(O 、100 、300 、500)及進料濃度(0 .2 5 、 0.5 、1 、2 kg/m) ，在低進料濃度(0.25 kg/m)及高攪拌速度(500 rpm)下，當操作壓力大於150 kPa時，已接近極限濾速區戚。在溶液pH=3 時， HA分子較接近為球狀粒子，堆積形態緊密，濾速相對較低;濃度高時，因溶液黏度較高會產生較大的過濾阻力使得濾速較低。濃縮程序中，在攪拌速度為500 rpm 下，可將HA 濃度從0.5 kg/m 濃縮至1.5 kg/m，隨著槽內濃度及黏度上升濾速降低，於濃縮後期因薄膜表面膠層形成，濃度極化阻力急劇上升。This study investigated the diafiltration and concentration of HA solution in a dead-end stirred cell. The flux behavior, HA rejection and filtration resistance were discussed under various operating parameters such as pH value (3,5, 7 and 13), stirred rate (0, 100,300 and 500 rpm) and feed concentration (0.25, 0.5, 1 and 2 kg/m ). At low feed concentration (0 .25 kg/m ) and high stirred rate (500 rpm), the limiting flux region was reached as the operation pressure exceeded 150 kPa. For pH = 3, the permeate was relatively low due to the fact that the HA molecule is close to a spheroid particle and results in a compact polarization layer. The filtration resistance increased with the increase of feed concentration due to the increment of feed viscosity. At 500 rpm, the 0.5 kg/m HA solution was concentrated to 1.5 kg/m . The permeate flux decreased with the increases of solution concentration and viscosity in the stirred cell. Moreover, the filtration resistance increased hugely at the late stage of concentration due to the formation of gel layer on the membrane surface.
Relation:	2008年輸送現象及其應用研討會論文摘要集 ( 2008 Symposium of transport phenomena and applications abstract book)
Appears in Collections:	[Graduate Institute & Department of Chemical and Materials Engineering] Proceeding

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