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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/71405

    Title: 攪拌透析過濾玻尿酸溶液濾速行為之研究
    Other Titles: Flux Behavior of Hyaluronic Acid Solution in Stirred Diafiltration
    Authors: 鄭東文;Cheng, Tung-wen;許哲榮;Hsu, C.J.
    Contributors: 淡江大學化學工程與材料工程學系
    Keywords: 透析過濾;玻尿酸;攪拌槽;濃度極化;Diafiltration;Hyaluronic acid;Stirred cell;Concentration polarization
    Date: 2008
    Issue Date: 2012-12-03 23:30:15 (UTC+8)
    Publisher: 臺北市:行政院國家科學委員會
    Abstract: 本研究以恆壓過濾系統,採透析過濾及濃縮程序
    (3 、5 、7 、13) 、rpm(O 、100 、300 、500)及進料濃度(0 .2 5 、
    0.5 、1 、2 kg/m) ,在低進料濃度(0.25 kg/m)及高攪拌
    速度(500 rpm)下,當操作壓力大於150 kPa時,已接近
    極限濾速區戚。在溶液pH=3 時, HA分子較接近為球狀
    程序中,在攪拌速度為500 rpm 下,可將HA 濃度從0.5
    kg/m 濃縮至1.5 kg/m,隨著槽內濃度及黏度上升濾速
    急劇上升。This study investigated the diafiltration and
    concentration of HA solution in a dead-end stirred cell.
    The flux behavior, HA rejection and filtration resistance
    were discussed under various operating parameters such as
    pH value (3,5, 7 and 13), stirred rate (0, 100,300 and 500
    rpm) and feed concentration (0.25, 0.5, 1 and 2 kg/m ). At
    low feed concentration (0 .25 kg/m ) and high stirred rate
    (500 rpm), the limiting flux region was reached as the
    operation pressure exceeded 150 kPa. For pH = 3, the
    permeate was relatively low due to the fact that the HA
    molecule is close to a spheroid particle and results in a
    compact polarization layer. The filtration resistance
    increased with the increase of feed concentration due to
    the increment of feed viscosity. At 500 rpm, the 0.5 kg/m
    HA solution was concentrated to 1.5 kg/m . The permeate
    flux decreased with the increases of solution concentration
    and viscosity in the stirred cell. Moreover, the filtration
    resistance increased hugely at the late stage of concentration due to the formation of gel layer on the
    membrane surface.
    Relation: 2008年輸送現象及其應用研討會論文摘要集 ( 2008 Symposium of transport phenomena and applications abstract book)
    Appears in Collections:[Graduate Institute & Department of Chemical and Materials Engineering] Proceeding

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