Immobilization of heparin on PVDF membranes with microporous structures

doi:10.1016/j.memsci.2004.07.028

淡江大學機構典藏 > 工學院 > 化學工程與材料工程學系暨研究所 > 期刊論文 > Item 987654321/71200

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題名:	Immobilization of heparin on PVDF membranes with microporous structures
作者:	Lin, Dar-jong;Lin, Dong-tsamn;Young, Tai-horng;Huang, Fang-ming;Chen, Ching-chung;Cheng, Liao-ping
貢獻者:	淡江大學化學工程與材料工程學系
關鍵詞:	Composite membranes;Plasma polymerized membranes;Immobilization;Heparin
日期:	2004-12-01
上傳時間:	2011-10-24 00:57:32 (UTC+8)
摘要:	Heparin (an anti-thrombin) was immobilized onto microporous poly (vinylidene fluoride) (PVDF) membranes that were prepared either by dry or immersion precipitation method. Immobilization of heparin was carried out by a procedure consisted of two steps. First, poly (acrylic acid) (PAA) was grafted on PVDF membranes with various surface porosities by plasma-induced polymerization. Then, heparin was covalently bonded to PAA with the aid of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (EDAC). The highest attainable grafting yield of PAA was 0.68 mg/cm2. For heparin immobilization, it was found that the preparation parameters such as, EDAC activation time, concentration of reactants, and pH affected significantly the amount of immobilized heparin. The maximal value was 9.68 μg/cm2. Furthermore, blood compatibility tests were carried out on membranes with and without heparin by platelet adhesion method. The results indicated that immobilized-heparin could effectively inhibit platelet adhesion on the membranes.
關聯:	Journal of membrane science 245(1-2), pp.137-146
DOI:	10.1016/j.memsci.2004.07.028
顯示於類別:	[化學工程與材料工程學系暨研究所] 期刊論文

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