English  |  正體中文  |  简体中文  |  Items with full text/Total items : 57615/91160 (63%)
Visitors : 13541637      Online Users : 296
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/71200

    Title: Immobilization of heparin on PVDF membranes with microporous structures
    Authors: Lin, Dar-jong;Lin, Dong-tsamn;Young, Tai-horng;Huang, Fang-ming;Chen, Ching-chung;Cheng, Liao-ping
    Contributors: 淡江大學化學工程與材料工程學系
    Keywords: Composite membranes;Plasma polymerized membranes;Immobilization;Heparin
    Date: 2004-12-01
    Issue Date: 2011-10-24 00:57:32 (UTC+8)
    Abstract: Heparin (an anti-thrombin) was immobilized onto microporous poly (vinylidene fluoride) (PVDF) membranes that were prepared either by dry or immersion precipitation method. Immobilization of heparin was carried out by a procedure consisted of two steps. First, poly (acrylic acid) (PAA) was grafted on PVDF membranes with various surface porosities by plasma-induced polymerization. Then, heparin was covalently bonded to PAA with the aid of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (EDAC). The highest attainable grafting yield of PAA was 0.68 mg/cm2. For heparin immobilization, it was found that the preparation parameters such as, EDAC activation time, concentration of reactants, and pH affected significantly the amount of immobilized heparin. The maximal value was 9.68 μg/cm2. Furthermore, blood compatibility tests were carried out on membranes with and without heparin by platelet adhesion method. The results indicated that immobilized-heparin could effectively inhibit platelet adhesion on the membranes.
    Relation: Journal of membrane science 245(1-2), pp.137-146
    DOI: 10.1016/j.memsci.2004.07.028
    Appears in Collections:[Graduate Institute & Department of Chemical and Materials Engineering] Journal Article

    Files in This Item:

    There are no files associated with this item.

    All items in 機構典藏 are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback