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    Title: Immobilization of heparin on PVDF membranes with microporous structures
    Authors: Lin, Dar-jong;Lin, Dong-tsamn;Young, Tai-horng;Huang, Fang-ming;Chen, Ching-chung;Cheng, Liao-ping
    Contributors: 淡江大學化學工程與材料工程學系
    Keywords: Composite membranes;Plasma polymerized membranes;Immobilization;Heparin
    Date: 2004-12-01
    Issue Date: 2011-10-24 00:57:32 (UTC+8)
    Abstract: Heparin (an anti-thrombin) was immobilized onto microporous poly (vinylidene fluoride) (PVDF) membranes that were prepared either by dry or immersion precipitation method. Immobilization of heparin was carried out by a procedure consisted of two steps. First, poly (acrylic acid) (PAA) was grafted on PVDF membranes with various surface porosities by plasma-induced polymerization. Then, heparin was covalently bonded to PAA with the aid of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (EDAC). The highest attainable grafting yield of PAA was 0.68 mg/cm2. For heparin immobilization, it was found that the preparation parameters such as, EDAC activation time, concentration of reactants, and pH affected significantly the amount of immobilized heparin. The maximal value was 9.68 μg/cm2. Furthermore, blood compatibility tests were carried out on membranes with and without heparin by platelet adhesion method. The results indicated that immobilized-heparin could effectively inhibit platelet adhesion on the membranes.
    Relation: Journal of membrane science 245(1-2), pp.137-146
    DOI: 10.1016/j.memsci.2004.07.028
    Appears in Collections:[Graduate Institute & Department of Chemical and Materials Engineering] Journal Article

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