Based on the empirical formulas for power spectra of generalized modal forces and local fluctuating wind forces in across-wind and torsional directions, the wind-induced lateral-torsional coupled response analysis of a representative rectangular tall building was conducted by setting various parameters such as eccentricities in centers of mass and/or rigidity and considering different torsional to lateral stiffness ratios. The eccentricity effects on the lateral-torsional coupled responses of the tall building were studied comprehensively by structural dynamic analysis. Extensive computational results indicated that the torsional responses at the geometric center of the building may be significantly affected by the eccentricities in the centers of mass and/or rigidity. Covariance responses were found to be in the same order of magnitude as the along-wind or across-wind responses in many eccentricity cases, suggesting that the lateral-torsional coupled effects on the overall wind-induced responses can not be neglected for such situations. The calculated results also demonstrated that the torsional motion contributed significantly to the total responses of rectangular tall buildings with mass and/or rigidity eccentricities. It was shown through this study that the framework presented in this paper provides a useful tool to evaluate the wind-induced lateral-torsional coupled responses of rectangular buildings, which will enable structural engineers in the preliminary design stages to assess the serviceability of tall buildings, potential structural vibration problems and the need for a detailed wind tunnel test.