Testing for Differently Expressed Genes with Microarray Data

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題名:	Testing for Differently Expressed Genes with Microarray Data
作者:	陳怡如;Chen, James J.;Tsai, Chen-an
貢獻者:	淡江大學統計學系
日期:	2003-08
上傳時間:	2011-10-23 16:43:12 (UTC+8)
摘要:	This paper compares the type I error and power of the one‐ and two‐sample t‐tests, and the one‐ and two‐sample permutation tests for detecting differences in gene expression between two microarray samples with replicates using Monte Carlo simulations. When data are generated from a normal distribution, type I errors and powers of the one‐sample parametric t‐test and one‐sample permutation test are very close, as are the two‐sample t‐test and two‐sample permutation test, provided that the number of replicates is adequate. When data are generated from a t‐distribution, the permutation tests outperform the corresponding parametric tests if the number of replicates is at least five. For data from a two‐color dye swap experiment, the one‐sample test appears to perform better than the two‐sample test since expression measurements for control and treatment samples from the same spot are correlated. For data from independent samples, such as the one‐channel array or two‐channel array experiment using reference design, the two‐sample t‐tests appear more powerful than the one‐sample t‐tests.
關聯:	Nuclei Acids Research 37(9), pp.e52
DOI:	10.1093/nar/gng052
顯示於類別:	[統計學系暨研究所] 期刊論文

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