Statistics for Risk Assessment of Chemical Carcinogens

doi:10.1080/10590500701703989

淡江大學機構典藏 > 商管學院 > 統計學系暨研究所 > 期刊論文 > Item 987654321/69239

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题名:	Statistics for Risk Assessment of Chemical Carcinogens
作者:	Chen, James J.;Chen, Yi-Ju;Cheng, Kuang-Fu
贡献者:	淡江大學統計學系
关键词:	Benchmark Dose;Carcinogenicity Bioassay;Chemical Mixture;Cumulative Risk;Hierarchical Model;Point of Departure;Probabilistic Risk Assessment;Reference Dose
日期:	2007
上传时间:	2011-10-23 16:42:13 (UTC+8)
出版者:	Philadelphia: Taylor & Francis Inc.
摘要:	Risk assessment is a scientific process of evaluation of potential health risks of chemical exposures to humans from available information. It involves analysis of the relationship between exposure and health related outcomes to derive an allowable exposure level. Because of lack of human exposure data, the major source of information for studying potential health effects of chemicals on humans is generally obtained from animal dose response experiments. Animal data are often evaluated in two aspects via statistical analysis: qualitative testing and quantitative estimation. The qualitative testing is to determine if the chemical causes an adverse health effect, i.e., if there is a statistically significant difference between treated and control animals. Quantitative estimation involves fitting a dose-response model to derive an allowable exposure level for humans. This paper reviews statistical principles and procedures for qualitative and quantitative approaches to human risk assessment.
關聯:	Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews 25(4), pp.281-312
DOI:	10.1080/10590500701703989
显示于类别:	[統計學系暨研究所] 期刊論文

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