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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/69239


    Title: Statistics for Risk Assessment of Chemical Carcinogens
    Authors: Chen, James J.;Chen, Yi-Ju;Cheng, Kuang-Fu
    Contributors: 淡江大學統計學系
    Keywords: Benchmark Dose;Carcinogenicity Bioassay;Chemical Mixture;Cumulative Risk;Hierarchical Model;Point of Departure;Probabilistic Risk Assessment;Reference Dose
    Date: 2007
    Issue Date: 2011-10-23 16:42:13 (UTC+8)
    Publisher: Philadelphia: Taylor & Francis Inc.
    Abstract: Risk assessment is a scientific process of evaluation of potential health risks of chemical exposures to humans from available information. It involves analysis of the relationship between exposure and health related outcomes to derive an allowable exposure level. Because of lack of human exposure data, the major source of information for studying potential health effects of chemicals on humans is generally obtained from animal dose response experiments. Animal data are often evaluated in two aspects via statistical analysis: qualitative testing and quantitative estimation. The qualitative testing is to determine if the chemical causes an adverse health effect, i.e., if there is a statistically significant difference between treated and control animals. Quantitative estimation involves fitting a dose-response model to derive an allowable exposure level for humans. This paper reviews statistical principles and procedures for qualitative and quantitative approaches to human risk assessment.
    Relation: Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews 25(4), pp.281-312
    DOI: 10.1080/10590500701703989
    Appears in Collections:[Graduate Institute & Department of Statistics] Journal Article

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