淡江大學機構典藏:Item 987654321/69174
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    题名: Bayesian Analysis of the Population Case-Control Studies When the Population is in Hardy-Weinberg Equilibrium
    作者: 陳錦華;Chen, Jin-hua
    贡献者: 淡江大學統計學系
    日期: 2005-02
    上传时间: 2011-10-23 16:29:57 (UTC+8)
    摘要: Association analysis of genetic polymorphisms has been mostly performed in a case-control setting with unrelated affected subjects compared with unrelated unaffected subjects. In this paper, we present a Bayesian method for analyzing such case-control data when the population is in Hardy-Weinberg equilibrium. Our Bayesian method depends on the informative prior which is the retrospective likelihood based on historical data, raised to a power a. By modeling the retrospective likelihood properly, different prior information about the studied population can be incorporated into the specification of the prior. The scalar a is a precision parameter quantifying the heterogeneity between current and historical data. A guide value for a is discussed in this paper. The informative prior and posterior distributions are proper under very general conditions. Therefore, our method can be applied in most case-control studies. Further, for assessing gene-environment interactions, our approach will naturally lead to a Bayesian model depending only on the case data, when genotype and environmental factors are independent in the population. Thus our approach can be applied to case-only studies. A real example is used to show the applications of our method.
    關聯: Genetics Epidemiology 28(2), pp.183-193
    DOI: 10.1002/gepi.20044
    显示于类别:[統計學系暨研究所] 期刊論文

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