An Adaptive Design for Categorical Responses in Phase III Clinical Trials

淡江大學機構典藏 > 商管學院 > 管理科學學系暨研究所 > 期刊論文 > Item 987654321/64963

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題名:	An Adaptive Design for Categorical Responses in Phase III Clinical Trials
作者:	黃文濤;Atanu Biswas;Rahul Bhattacharya
貢獻者:	淡江大學經營決策學系
關鍵詞:	immigration ball;limiting proportion of allocation;ordinal categorical responses;proportion of allocation;randomisation;response-driven adaptive design;treatment difference;urn model
日期:	2007-01
上傳時間:	2011-10-20 16:14:13 (UTC+8)
摘要:	An adaptive design is provided for phase III clinical trials where the treatment responses are categorical. The proposed design extends the drop-the-loser rule (Ivanova [10]) which is proposed for binary treatment responses only. It is illustrated that the proposed design is an improvement over the existing design of Bandyopadhyay and Biswas [3] for such categorical responses in terms of low variability. Some probability generating functions of the proposed design are obtained. The applicability of the proposed design is illustrated by using some real data from an trial of patients of rheumatoid arthritis.
關聯:	International Journal of Information and Management Sciences 18(1), pp.1-16
顯示於類別:	[管理科學學系暨研究所] 期刊論文

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