淡江大學機構典藏:Item 987654321/64963
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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/64963


    Title: An Adaptive Design for Categorical Responses in Phase III Clinical Trials
    Authors: 黃文濤;Atanu Biswas;Rahul Bhattacharya
    Contributors: 淡江大學經營決策學系
    Keywords: immigration ball;limiting proportion of allocation;ordinal categorical responses;proportion of allocation;randomisation;response-driven adaptive design;treatment difference;urn model
    Date: 2007-01
    Issue Date: 2011-10-20 16:14:13 (UTC+8)
    Abstract: An adaptive design is provided for phase III clinical trials where the treatment responses are categorical. The proposed design extends the drop-the-loser rule (Ivanova [10]) which is proposed for binary treatment responses only. It is illustrated that the proposed design is an improvement over the existing design of Bandyopadhyay and Biswas [3] for such categorical responses in terms of low variability. Some probability generating functions of the proposed design are obtained. The applicability of the proposed design is illustrated by using some real data from an trial of patients of rheumatoid arthritis.
    Relation: International Journal of Information and Management Sciences 18(1), pp.1-16
    Appears in Collections:[Department of Management Sciences] Journal Article

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