淡江大學機構典藏:Item 987654321/64165
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 58605/92268 (64%)
造訪人次 : 548528      線上人數 : 76
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/64165


    題名: Lack of association between AKT1 variances versus clinical manifestations and social function in patients with schizophrenia
    作者: Liu, Yi-Ching;Huang, C.L.;Wu, P.L.;Chang, Y.C.;Huang, C.H.;Lane, Hsien-Yuan
    貢獻者: 淡江大學數學學系
    關鍵詞: AKT;antipsychotics;negative symptoms;positive symptoms;social function
    日期: 2009-11
    上傳時間: 2011-10-20 12:47:57 (UTC+8)
    出版者: London: Sage Publications Ltd.
    摘要: The elucidation of genotype-phenotype relationships in psychiatric research is at an early stage. V-akt murine thymoma viral oncogene homolog 1 (AKT1) is a serine/threonine kinase known as protein kinase B. Emerging studies have implicated the role of AKT1 in pathogenesis of schizophrenia; however, the findings have not been consistent. This study aims to examine the association of AKT1 polymorphisms with drug-free and post-treatment symptomatology and social function in patients with schizophrenia. One hundred and twenty newly hospitalised patients with acutely exacerbated schizophrenia who had never been treated by atypical antipsychotics were recruited. They received optimal treatment of risperidone for up to 42 days in the inpatient research unit. Clinical manifestations were monitored by Positive and Negative Syndrome Scale (PANSS) and social function by Nurses’ Observation Scale for Inpatients Evaluation (NOSIE). Patients were genotyped for eight AKT1 Single Nucleotide Polymorphism (SNPs), which have been previously investigated for association with schizophrenia. At drug-free status and after best possible treatment of risperidone, genotypes of each SNP did not influence performances in NOSIE, PANSS-total, -positive, -negative and -general psychopathology profiles. These results suggest that AKT1 does not play a significant role in clinical and functional manifestations in patients with schizophrenia who receive risperidone treatment. Future research should also focus on the relationships between genotypes of other susceptibility genes and phenotypes or functional outcomes of schizophrenia.
    關聯: Journal of Psychopharmacology 23(8), pp.937-943
    DOI: 10.1177/0269881108093840
    顯示於類別:[數學學系暨研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    0269-8811_23(8)p937-943.pdf8065KbAdobe PDF3檢視/開啟
    index.html0KbHTML56檢視/開啟

    在機構典藏中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋