Human aldehyde dehydrogenase E3 isozyme is a betaine aldehyde dehydrogenase

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Title:	Human aldehyde dehydrogenase E3 isozyme is a betaine aldehyde dehydrogenase
Authors:	Chern, Ming-kai;Pietruszko, Regina
Contributors:	淡江大學生命科學研究所
Date:	1995-08
Issue Date:	2013-05-31 11:33:25 (UTC+8)
Publisher:	Maryland Heights: Academic Press
Abstract:	The E3 isozyme of human aldehyde dehydrogenase (EC 1.2.1.3), with broad substrate specificity, which also catalyzes dehydrogenation of 4-aminobutyraldehyde, was purified and sequenced recently (1,3). It has been shown during this investigation to have betaine aldehyde dehydrogenase activity. Betaine aldehyde and 4-aminobutyraldehyde activities copurified on six chromatographic columns. Molecular properties of the homogeneous product were identical with those of E3 isozyme. Activity with betaine aldehyde was considerably higher than that with 4-aminobutyraldehyde, the best known substrate. Thus, human E3 isozyme and betaine aldehyde dehydrogenase (EC 1.2.1.8) are the same enzyme.
Relation:	Biochemical and Biophysical Research Communications 213(2), pp.561-568
DOI:	10.1006/bbrc.1995.2168
Appears in Collections:	[Graduate Institue of Life Sciences] Journal Article

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