Val-9Ala and Ile + 58Thr polymorphism of MnSOD in Parkinson's disease

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/61791

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题名:	Val-9Ala and Ile + 58Thr polymorphism of MnSOD in Parkinson's disease
作者:	Wang, Vinchi;Chen, Shao-yuan;Chuang, Tzu-chao;Shan, Din-e;Soong, Bing-wen;Kao, Ming-ching
贡献者:	淡江大學化學學系
关键词:	Genetic polymorphism;Mn-SOD;Parkinson disease
日期:	2010-08
上传时间:	2011-10-15 23:40:55 (UTC+8)
出版者:	Elsevier Inc.
摘要:	Objectives: To investigate the polymorphism distribution of Val-9Ala and Ile+58Thr of the Mn-superoxide dismutase (Mn-SOD) gene among subjects with Parkinson's disease (PD) by analyses of genders and clinical severity. Design and methods: We examined the DNA genotypes of Val-9Ala and Ile+58Thr from 295 PD subjects and 111 controls by nucleotide sequencing and BsaWI restriction. Results: Ala/Ala homozygosity was found in four PD subjects but not in the controls. All of the genotypes at codon +58 among the examined samples were Ile/Ile homozygotes. Although higher carrier rate of Ala allele among PD subjects than the controls, there were no differences by analyses of the genders and clinical severity. Conclusion: The higher Ala-allele carrier rate among PD subjects may suggest a possible higher amount of mitochondrial Mn-SOD rendering higher intracellular stress in PD. In this study the polymorphisms at codons -9 and+58 did not give informative association evidences with PD.
關聯:	Clinical Biochemistry 43(12), p.979-982
DOI:	10.1016/j.clinbiochem.2010.05.009
显示于类别:	[化學學系暨研究所] 期刊論文

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