English  |  正體中文  |  简体中文  |  Items with full text/Total items : 62796/95837 (66%)
Visitors : 3641360      Online Users : 496
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/61791


    Title: Val-9Ala and Ile + 58Thr polymorphism of MnSOD in Parkinson's disease
    Authors: Wang, Vinchi;Chen, Shao-yuan;Chuang, Tzu-chao;Shan, Din-e;Soong, Bing-wen;Kao, Ming-ching
    Contributors: 淡江大學化學學系
    Keywords: Genetic polymorphism;Mn-SOD;Parkinson disease
    Date: 2010-08
    Issue Date: 2011-10-15 23:40:55 (UTC+8)
    Publisher: Philadelphia: Elsevier Inc.
    Abstract: Objectives:
    To investigate the polymorphism distribution of Val-9Ala and Ile + 58Thr of the Mn-superoxide dismutase (Mn-SOD) gene among subjects with Parkinson's disease (PD) by analyses of genders and clinical severity.
    Design and Methods:
    We examined the DNA genotypes of Val-9Ala and Ile + 58Thr from 295 PD subjects and 111 controls by nucleotide sequencing and BsaWI restriction.
    Results:
    Ala/Ala homozygosity was found in four PD subjects but not in the controls. All of the genotypes at codon + 58 among the examined samples were Ile/Ile homozygotes. Although higher carrier rate of Ala allele among PD subjects than the controls, there were no differences by analyses of the genders and clinical severity.
    Conclusion:
    The higher Ala-allele carrier rate among PD subjects may suggest a possible higher amount of mitochondrial Mn-SOD rendering higher intracellular stress in PD. In this study the polymorphisms at codons -9 and + 58 did not give informative association evidences with PD.
    Relation: Clinical Biochemistry 43(12), pp.979-982
    DOI: 10.1016/j.clinbiochem.2010.05.009
    Appears in Collections:[化學學系暨研究所] 期刊論文

    Files in This Item:

    File Description SizeFormat
    0009-9120_43(12)p979-982.pdf173KbAdobe PDF289View/Open
    0009-9120_43(12)p979-982.pdf173KbAdobe PDF1View/Open

    All items in 機構典藏 are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback