The N-terminal domain of EBNA1 acts as a suppressor of the HER2/neu oncogene

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/61771

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題名:	The N-terminal domain of EBNA1 acts as a suppressor of the HER2/neu oncogene
作者:	Liu, Jah-yao;Chuang, Tzu-chao;Way, Tzong-der;Tsai, Tzung-chieh;Hu, Chih-lin;Liu, Guang-yaw;Wang, Shan-shue;Chung, Jing-gung;Kao, Ming-ching
貢獻者:	淡江大學化學學系
關鍵詞:	HER2/neu;EBV;EBNA1;Cell cycle;Gene therapy
日期:	2009-01-18
上傳時間:	2011-10-15 23:38:50 (UTC+8)
出版者:	Shannon： Elsevier Ireland Ltd
摘要:	HER2/neu oncogene-mediated malignancy is clearly associated with various human cancers. Therefore, HER2/neu targeting is an effective approach to cancer therapy. We have previously demonstrated that Epstein–Barr virus nuclear antigen-1 (EBNA1) can suppress HER2/neu oncogene expression, although EBNA1 itself has oncogenic potential. Here, we found that the N-terminal domain of EBNA1 alone, named EBNA1-NT, which contains the N-terminal region of amino acid residues 1–86 of EBNA1, is required and sufficient to suppress HER2/neu oncogene expression at the transcriptional level. Furthermore, in EBNA1-NT-transfected HER2/neu-overexpressing cells, we found EBNA1-NT could down-regulate the endogenous production of p185HER2/neu, lower transformation ability, sensitize paclitaxel-induced apoptosis and decrease tumorigenic potential. These data suggest that EBNA1-NT may act as a repressor of the HER2/neu oncogene.
關聯:	Cancer Letters 273(2), pp.273-280
DOI:	10.1016/j.canlet.2008.08.013
顯示於類別:	[化學學系暨研究所] 期刊論文

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