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    Title: Novel Water-Soluble 4,4-Disubstituted Ruthenium(III)-Salen Complexes in DNA Stranded Scission
    Authors: 鄭建中;Cheng, Chien-chung;呂燕凌;Lu, Yen-ling
    Contributors: 淡江大學化學學系
    Keywords: Ruthenium;Salen;Dna Cleavage;Hairpin Type Triplex
    釕;沙林;去氧核糖核酸剝離;髮夾式三螺旋
    Date: 1998-10-01
    Issue Date: 2013-07-11 11:28:30 (UTC+8)
    Publisher: 臺北市:中國化學學會
    Abstract: Salen-type Ru(III) complexes are found to be capable of reacting with physiologically acceptable oxidants. The water solubility and DNA affinity of these Ru(III)-salen complexes are enhanced by the utilization of a variety of charged groups through the formation of peptide bonds. In the presence of hydrogen peroxide, modified Ru(III)-salen complexes are capable of nicking DNA. In addition, the reactivity in DNA cleavage increases along with the total number of positive charges retaining in Ru( III)-salen complexes and less influence in the electronic effect. Using /sup 32/P-end-labeled oligonucleotides and high resolution polyacrylamide gel electrophoresis, Ru(III)-salen complexes are found to randomly cleave DNA regardless of the DNA secondary conformation such as bulge, inter-loop, or double-stranded regions. The possible reactive species of Ru(III)-salen complexes in DNA cleavage is considered as the hydroxyl radical and high valent oxoruthenium (IV) species according to the UV titration, quenching studies, and reaction with varied oxidants.
    Relation: Journal of the Chinese Chemical Society=中國化學會會誌 45(5), pp.611-617
    DOI: 10.1002/jccs.199800092
    Appears in Collections:[化學學系暨研究所] 期刊論文

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