淡江大學機構典藏:Item 987654321/61608
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 55542/89862 (62%)
造访人次 : 11012544      在线人数 : 20
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/61608


    题名: Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: In vitro and in vivo
    作者: Chuang, Tzu-chao;Hsu, Shih-chung;Ou, Chien-chih;Li, Jhy-wei;Lee, Yi-jen;Wang, Vinchi;Liu, Jah-yao;Chen, Chin-shiang;Lin, Song-chow;Kao, Ming-ching
    贡献者: 淡江大學化學學系
    关键词: Ganoderma tsugae;Epidermal growth factor receptor;Anti-angiogenesis;Vascular endothelial growth factor;Epidermoid carcinoma
    日期: 2009-08-01
    上传时间: 2011-10-15 23:21:25 (UTC+8)
    出版者: Shannon: Elsevier Ireland Ltd
    摘要: We examined the anti-angiogenic effects of Ganoderma tsugae methanol extract (GTME) on human epidermoid carcinoma A-431 cells. Our data indicate that GTME inhibits the expression of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) in vitro and in vivo, and also inhibits the capillary tube formation of human umbilical vein endothelial cells (HUVECs). We also show that the suppression of VEGF expression by GTME can be restored by treatment with EGF. These results suggest that GTME inhibits VEGF expression via the suppression of EGFR expression, resulting in the downregulation of VEGF secretion from epidermoid carcinoma A-431 cells. These findings reveal a novel role for G. tsugae in inhibiting EGFR and VEGF expression, which are important for tumor angiogenesis and growth. Thus, GTME may provide a potential therapeutic approach for anti-tumor treatment.
    關聯: Cancer Letters 281(1), pp.108-116
    DOI: 10.1016/j.canlet.2009.02.032
    显示于类别:[化學學系暨研究所] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML233检视/开启
    index.html0KbHTML94检视/开启

    在機構典藏中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈