Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: In vitro and in vivo

doi:10.1016/j.canlet.2009.02.032

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/61608

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/61608

题名:	Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: In vitro and in vivo
作者:	Chuang, Tzu-chao;Hsu, Shih-chung;Ou, Chien-chih;Li, Jhy-wei;Lee, Yi-jen;Wang, Vinchi;Liu, Jah-yao;Chen, Chin-shiang;Lin, Song-chow;Kao, Ming-ching
贡献者:	淡江大學化學學系
关键词:	Ganoderma tsugae;Epidermal growth factor receptor;Anti-angiogenesis;Vascular endothelial growth factor;Epidermoid carcinoma
日期:	2009-08-01
上传时间:	2011-10-15 23:21:25 (UTC+8)
出版者:	Shannon: Elsevier Ireland Ltd
摘要:	We examined the anti-angiogenic effects of Ganoderma tsugae methanol extract (GTME) on human epidermoid carcinoma A-431 cells. Our data indicate that GTME inhibits the expression of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) in vitro and in vivo, and also inhibits the capillary tube formation of human umbilical vein endothelial cells (HUVECs). We also show that the suppression of VEGF expression by GTME can be restored by treatment with EGF. These results suggest that GTME inhibits VEGF expression via the suppression of EGFR expression, resulting in the downregulation of VEGF secretion from epidermoid carcinoma A-431 cells. These findings reveal a novel role for G. tsugae in inhibiting EGFR and VEGF expression, which are important for tumor angiogenesis and growth. Thus, GTME may provide a potential therapeutic approach for anti-tumor treatment.
關聯:	Cancer Letters 281(1), pp.108-116
DOI:	10.1016/j.canlet.2009.02.032
显示于类别:	[化學學系暨研究所] 期刊論文

文件中的档案:

档案	大小	格式	浏览次数
index.html	0Kb	HTML	50	检视/开启

在機構典藏中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....