淡江大學機構典藏:Item 987654321/61608
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    Title: Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: In vitro and in vivo
    Authors: Chuang, Tzu-chao;Hsu, Shih-chung;Ou, Chien-chih;Li, Jhy-wei;Lee, Yi-jen;Wang, Vinchi;Liu, Jah-yao;Chen, Chin-shiang;Lin, Song-chow;Kao, Ming-ching
    Contributors: 淡江大學化學學系
    Keywords: Ganoderma tsugae;Epidermal growth factor receptor;Anti-angiogenesis;Vascular endothelial growth factor;Epidermoid carcinoma
    Date: 2009-08-01
    Issue Date: 2011-10-15 23:21:25 (UTC+8)
    Publisher: Shannon: Elsevier Ireland Ltd
    Abstract: We examined the anti-angiogenic effects of Ganoderma tsugae methanol extract (GTME) on human epidermoid carcinoma A-431 cells. Our data indicate that GTME inhibits the expression of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) in vitro and in vivo, and also inhibits the capillary tube formation of human umbilical vein endothelial cells (HUVECs). We also show that the suppression of VEGF expression by GTME can be restored by treatment with EGF. These results suggest that GTME inhibits VEGF expression via the suppression of EGFR expression, resulting in the downregulation of VEGF secretion from epidermoid carcinoma A-431 cells. These findings reveal a novel role for G. tsugae in inhibiting EGFR and VEGF expression, which are important for tumor angiogenesis and growth. Thus, GTME may provide a potential therapeutic approach for anti-tumor treatment.
    Relation: Cancer Letters 281(1), pp.108-116
    DOI: 10.1016/j.canlet.2009.02.032
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

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