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    Title: EBNA1 may prolong G2/M phase and sensitizes HER2/neu-overexpressing ovarian cells to both topoisomerase II-targeting and paclitaxel drugs
    Authors: Chuang, TC;Lee, YJ;Liu, JY;Lin, YS;Lee, JW;Wang, V;Law, SL;Kao, Ming-Ching
    Contributors: 淡江大學化學學系
    Keywords: HER2/neu;EBNA1;Tumorigenicity;Ovarian cancer
    Date: 2003-08
    Issue Date: 2013-05-31 11:35:07 (UTC+8)
    Publisher: Maryland Heights: Academic Press
    Abstract: We have shown previously that the Epstein-Barr virus nuclear antigen-1 (EBNA1) can act as a transforming suppressor in the HER2/neu-overexpressing ovarian cancer cells. In the present study, by using flow cytometric analysis, we demonstrate that EBNA1 could prolong G(2)/M phase and sensitize to Taxol-induced apoptosis in the EBNA1-expressing ovarian cancer cell stable transfectants. In addition, EBNA1 could also significantly increase topoisomerase IIalpha protein expression, indicating that the up-regulation of topoisomerase IIalpha may be one of the mechanisms by which EBNA1 enhances the sensitivity of ovarian cancer cells to topoisomerase II-targeting anticancer drugs, such as VP-16 and Adriamycin. These data suggest that EBNA1 not only prolongs cell cycle at G(2)/M phase and up-regulates topoisomerase IIalpha expression in HER2/neu-overexpressing ovarian cancer cells, but also increases cellular apoptosis through sensitization of cancer cells to topoisomerase II-directing anticancer drugs.
    Relation: Biochemical and Biophysical Research Communications 307(3), pp.653-659
    DOI: 10.1016/S0006-291X(03)01235-X
    Appears in Collections:[化學學系暨研究所] 期刊論文

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