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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/61552

    Title: D-aminoacylase from alcaligenes faecalis possesses novel activities on D-met
    Authors: Chen, Hao-Ping;Wu, Shih-Hsiung;Wang, Kung-Tsung
    Contributors: 淡江大學化學學系
    Keywords: d-aminoacylase;enantioselectivity;acylation and deacylation;d-methionine;amino acids
    Date: 1994-01
    Issue Date: 2013-05-31 11:35:36 (UTC+8)
    Publisher: Kidlington: Pergamon
    Abstract: D-Aminoacylase isolated from Alcaligenes faecalis DA1 has a great potential for future application in D-amino acids production. This paper reports for the first time that D-aminoacylase can reverse the catalysis direction on D-Met and deacylate N-Ac-D-Met-OMe and N-Ac-D-Met-Gly. The results provide important insights regarding the binding and affinity of substrates to the active site of this enzyme. Based on a systematic study of kinetic properties and relative reactivities for a broad range of substrates, a model to elucidate the reaction mechanism is proposed.
    Relation: Bioorganic & Medicinal Chemistry: the Tetrahedron Journal For Research At the Interface of Chemistry and Biology 2(1), pp.1-5
    DOI: 10.1016/S0968-0896(00)82195-1 
    Appears in Collections:[化學學系暨研究所] 期刊論文

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