CoII(HAPP)(TFA)2 complexes : a DNA bulge-specific probe

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/61529

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題名:	CoII(HAPP)(TFA)2 complexes : a DNA bulge-specific probe
作者:	Wang, Wen-jwu
貢獻者:	淡江大學化學學系
關鍵詞:	Cobalt;DNA cleavage;DNA structures;Macrocycles;N ligands
日期:	1999-05-12
上傳時間:	2011-10-15 23:13:55 (UTC+8)
摘要:	Bulge cleavage of two or three bases occurs when a DNA substrate is specifically cleaved oxidatively by [CoII(tfa)2(happ)] (see picture). Hydrogen peroxide is necessary for the activation of this octahedral complex, which suggests that hydroxyl radicals are the reactive species. The complex has no significant reactivity towards the corresponding sequence in a single-stranded DNA region, and it exhibits only a low affinity towards double-stranded DNA. happ=macrocyclic ligand based on 1,10-phenanthroline, tfa=trifluoroacetate.
關聯:	Angewandte Chemie: International Edition in English 38(9), 　p.1255-1257
DOI:	10.1002/(SICI)1521-3773(19990503)38:9<1255::AID-ANIE1255>3.0.CO;2-T
顯示於類別:	[化學學系暨研究所] 期刊論文

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