淡江大學機構典藏:Item 987654321/61529
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 62830/95882 (66%)
Visitors : 4051553      Online Users : 1031
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/61529


    Title: CoII(HAPP)(TFA)2 complexes : a DNA bulge-specific probe
    Authors: Wang, Wen-jwu
    Contributors: 淡江大學化學學系
    Keywords: Cobalt;DNA cleavage;DNA structures;Macrocycles;N ligands
    Date: 1999-05-12
    Issue Date: 2011-10-15 23:13:55 (UTC+8)
    Abstract: Bulge cleavage of two or three bases occurs when a DNA substrate is specifically cleaved oxidatively by [CoII(tfa)2(happ)] (see picture). Hydrogen peroxide is necessary for the activation of this octahedral complex, which suggests that hydroxyl radicals are the reactive species. The complex has no significant reactivity towards the corresponding sequence in a single-stranded DNA region, and it exhibits only a low affinity towards double-stranded DNA. happ=macrocyclic ligand based on 1,10-phenanthroline, tfa=trifluoroacetate.
    Relation: Angewandte Chemie: International Edition in English 38(9), 　p.1255-1257
    DOI: 10.1002/(SICI)1521-3773(19990503)38:9<1255::AID-ANIE1255>3.0.CO;2-T
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

    Files in This Item:

    There are no files associated with this item.

    All items in 機構典藏 are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback