A New Co II Complex as a Bulge-Specific Probe for DNA

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Title:	A New Co II Complex as a Bulge-Specific Probe for DNA
Authors:	Cheng, Chien-chung;Kuo, Yen-ning;Chuang, Kuo-Shen;Luo, Chi-Fong;Wang, Wen Jwu
Contributors:	淡江大學化學學系
Keywords:	Cobalt;DNA cleavage;DNA structures;Macrocycles;N ligands
Date:	1999-05-12
Issue Date:	2013-05-31 11:34:49 (UTC+8)
Publisher:	Weinheim: WILEY-VCH Verlag GmbH
Abstract:	Bulge cleavage of two or three bases occurs when a DNA substrate is specifically cleaved oxidatively by [CoII(tfa)2(happ)] (see picture). Hydrogen peroxide is necessary for the activation of this octahedral complex, which suggests that hydroxyl radicals are the reactive species. The complex has no significant reactivity towards the corresponding sequence in a single-stranded DNA region, and it exhibits only a low affinity towards double-stranded DNA. happ=macrocyclic ligand based on 1,10-phenanthroline, tfa=trifluoroacetate.
Relation:	Angewandte Chemie International Edition 38(9), pp.1255-1257
DOI:	10.1002/(SICI)1521-3773(19990503)38:9<1255::AID-ANIE1255>3.0.CO;2-T
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

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