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    題名: A New Co II Complex as a Bulge-Specific Probe for DNA
    作者: Cheng, Chien-chung;Kuo, Yen-ning;Chuang, Kuo-Shen;Luo, Chi-Fong;Wang, Wen Jwu
    貢獻者: 淡江大學化學學系
    關鍵詞: Cobalt;DNA cleavage;DNA structures;Macrocycles;N ligands
    日期: 1900-01-01
    上傳時間: 2013-05-31 11:34:49 (UTC+8)
    出版者: Weinheim: WILEY-VCH Verlag GmbH
    摘要: Bulge cleavage of two or three bases occurs when a DNA substrate is specifically cleaved oxidatively by [CoII(tfa)2(happ)] (see picture). Hydrogen peroxide is necessary for the activation of this octahedral complex, which suggests that hydroxyl radicals are the reactive species. The complex has no significant reactivity towards the corresponding sequence in a single-stranded DNA region, and it exhibits only a low affinity towards double-stranded DNA. happ=macrocyclic ligand based on 1,10-phenanthroline, tfa=trifluoroacetate.
    關聯: Angewandte Chemie International Edition 38(9), pp.1255-1257
    DOI: 10.1002/(SICI)1521-3773(19990503)38:9<1255::AID-ANIE1255>3.0.CO;2-T
    顯示於類別:[化學學系暨研究所] 期刊論文

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