English  |  正體中文  |  简体中文  |  Items with full text/Total items : 49258/83761 (59%)
Visitors : 7139342      Online Users : 75
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/61487


    Title: A New Co II Complex as a Bulge-Specific Probe for DNA
    Authors: Cheng, Chien-chung;Kuo, Yen-ning;Chuang, Kuo-Shen;Luo, Chi-Fong;Wang, Wen Jwu
    Contributors: 淡江大學化學學系
    Keywords: Cobalt;DNA cleavage;DNA structures;Macrocycles;N ligands
    Date: 1999-05
    Issue Date: 2013-05-31 11:34:49 (UTC+8)
    Publisher: Weinheim: WILEY-VCH Verlag GmbH
    Abstract: Bulge cleavage of two or three bases occurs when a DNA substrate is specifically cleaved oxidatively by [CoII(tfa)2(happ)] (see picture). Hydrogen peroxide is necessary for the activation of this octahedral complex, which suggests that hydroxyl radicals are the reactive species. The complex has no significant reactivity towards the corresponding sequence in a single-stranded DNA region, and it exhibits only a low affinity towards double-stranded DNA. happ=macrocyclic ligand based on 1,10-phenanthroline, tfa=trifluoroacetate.
    Relation: Angewandte Chemie International Edition 38(9), pp.1255-1257
    DOI: 10.1002/(SICI)1521-3773(19990503)38:9<1255::AID-ANIE1255>3.0.CO;2-T
    Appears in Collections:[化學學系暨研究所] 期刊論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML181View/Open
    index.html0KbHTML40View/Open

    All items in 機構典藏 are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback