本研究利用無乳化劑乳化聚合來製備生物相容性佳且具備溫度敏感性質的的幾丁聚醣乳膠共聚物，一方面利用幾丁聚醣增加生物相容性，另一方面導入親水性單體PEGMA來提昇乳膠共聚物的LCST值。CS與NIPAAm共聚合的結果，其LCST值都約在32~33 degree C附近，與純PNIPAAm的LCST相差無幾，因此推測CS對LCST值的影響不大。CS、NIPAAm和PEGMA的乳膠共聚物，其LCST值大部分隨PEGMA的含量增加有提昇的效果，但因為單體反應性的不同，分別得到PNIPAAm-rich與PEGMA-rich的鏈段，而呈現兩段階段LCST。另外，觀察在不同反應時間取樣所得到產物的LCST值變化，發現除了10分鐘為一階段LCST之外，其餘皆為兩階段，而且隨反應時間增長，LCST值逐漸往低溫移動。 In this study, chitosan (CS) latex copolymer with excellent bi degree Compatible and thermal-responsive properties was synthesized with NIPAAm and PEGMA in an emulsifier-free emulsion polymerization. The LCST value of CS-PNIPAAm copolymer was 32-33 degree C almost the same as PNIPAAm. It implied that the CS did not influence the LCST value. Moreover, the LCST value of CS-PNIPAAm-PEGMA copolymer was increased with increasing the amount of hydrophilic PEGMA. However, two stages of transition behavior were observed because PNIPAAm-rich and PEGMA-rich chains were obtained due to the difference in monomer reactivity between NIPAAm and PEGMA. Therefore, different CS-PNIPAAm-PEGMA copolymers obtained at different reaction times would have different LCST values. As reaction pr degree Ceeded, the LCST shifted to lower temperature and two-transitions became obvious.
關聯:
2009中華民國高分子學會年會暨軟性電子國際研討會&國科會高分子學門成果發表會論文集=Proceedings of 2009 Annual Meeting of the Polymer Society，4頁
