English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 50123/85142 (59%)
造訪人次 : 7908163      線上人數 : 66
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/60172


    題名: Synthesis and characterization of stimuli-responsive porous/hollow nanoparticles by self-assembly of chitosan-based graft copolymers and application in drug release
    作者: Chuang, Chung-Yang;Don, Trong-Ming;Chiu, Wen-Yen
    貢獻者: 淡江大學化學工程與材料工程學系
    關鍵詞: graft copolymers;nanoparticles;polysaccharides;self-assembly;stimuli-response
    日期: 2010-06
    上傳時間: 2013-06-13 11:29:05 (UTC+8)
    出版者: Hoboken: John Wiley & Sons, Inc.
    摘要: In this research, stimuli-responsive porous/hollow nanoparticles were prepared by the self-assembly method. First, chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) copolymers were synthesized through polymerization of N-isopropylacrylamide (NIPAAm) monomer in the presence of chitosan (CS) solution using ceric ammounium nitrate as the initiator. Then, the CS-g-PNIPAAm copolymers were dissolved in the acetic acid aqueous solution and heated to 40 °C to induce their self-assembly. After CS-g-PNIPAAm assembled to form micelles, a cross-linking agent was used to reinforce the structure to form nanoparticles. The molecular weight of grafted PNIPAAm on CS chains was changed to investigate its effect on the structure, morphology, thermo-, and pH-responsive properties of the nanoparticles. TEM images showed that a porous or hollow structure in the interior of nanoparticles was developed, depending on the medium temperature. The synthesized nanoparticles carried positive charges on the surface and exhibited stimuli-responsive properties, and their mean diameter thus could be manipulated by changing the pH value and temperature of the environment. The nanoparticles showed a continuous release of the encapsulated doxycycline hyclate up to 10 days during an in vitro release experiment. These porous/hollow particles with environmentally sensitive properties are expected to be used in hydrophilic drug delivery system.
    關聯: Journal of Polymer Science Part A: Polymer Chemistry 48(11), pp.2377–2387
    DOI: 10.1002/pola.24006
    顯示於類別:[化學工程與材料工程學系暨研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    1099-0518_48(11)p2377-2387.pdf1196KbAdobe PDF149檢視/開啟

    在機構典藏中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋