淡江大學機構典藏:Item 987654321/60170
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    題名: Synthesis and properties of chitosan-based thermo- and pH-responsive nanoparticles and application in drug release
    作者: Chuang, Chung-Yang;Don, Trong-Ming;Chiu, Wen-Yen
    貢獻者: 淡江大學化學工程與材料工程學系
    關鍵詞: acrylic acid;chitosan;drug delivery systems;emulsion polymerization;N-isopropylacrylamide;nanoparticles;stimuli-sensitive polymers;thermo/pH response
    日期: 2009-06
    上傳時間: 2011-10-13 13:08:40 (UTC+8)
    出版者: Hoboken: John Wiley & Sons, Inc.
    摘要: In this research, thermo- and pH-responsive nanoparticles with an average diameter of about 50–200 nm were synthesized via the surfactant-free emulsion polymerization. The thermal/pH dual responsive properties of these nanoparticles were designed by the addition of a pH sensitive monomer, acrylic acid (AA), to be copolymerized with N-isopropylacrylamide (NIPAAm) in a chitosan (CS) solution. The molar ratio of CS/AA/NIPAAm in the feed was changed to investigate its effect on structure, morphology, thermal- and pH-responsive properties of the nanoparticles. It was found that CS-PAA-PNIPAAm nanoparticles could be well dispersed in the aqueous solution and carried positive charges on the surface. The addition of thermal-sensitive NIPAAm monomer affected the polymerization mechanism and interactions between CS and AA. The particle size of the nanoparticles was found to be varied with the composition of NIPAAm monomer in the feed. The synthesized nanoparticles exhibited stimuli-responsive properties, and their mean diameter thus could be manipulated by changing pH value and temperature of the environment. The nanoparticles showed a continuous release of the encapsulated doxycycline hyclate up to 10 days during an in vitro release experiment. The environmentally responsive nanoparticles are expected to be used in many fields such as drug delivery system.
    關聯: Journal of Polymer Science Part A: Polymer Chemistry 47(11), pp.2798–2810
    DOI: 10.1002/pola.23369
    顯示於類別:[化學工程與材料工程學系暨研究所] 期刊論文

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