Effects of dopamine D2 receptor ser311 polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function

doi:10.1017/S1461145704004389

淡江大學機構典藏 > 理學院 > 數學學系暨研究所 > 期刊論文 > Item 987654321/58825

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/58825

题名:	Effects of dopamine D2 receptor ser311 polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function
作者:	張玉坤;Cheng, Yue-cune
贡献者:	淡江大學數學學系
关键词:	Atypical antipsychotics;Chinese;DRD2;polymorphism;schizophrenia
日期:	2004-01
上传时间:	2011-10-01 21:14:08 (UTC+8)
摘要:	Risperidone is an atypical antipsychotic agent with efficacy for both positive and negative symptoms of schizophrenia. However, what makes an antipsychotic ‘atypical’ remains unclear. We recently found that the T102C polymorphism in the 5-HT2A receptor gene could affect risperidone's efficacy for negative symptoms. The present study investigated the effect of the Ser311Cys polymorphism in the dopamine D2 receptor (DRD2) gene on risperidone treatment response. A total of 123 Han Chinese patients with acutely exacerbated schizophrenia were given risperidone for up to 42 days. Clinical manifestations were measured bi-weekly with Positive and Negative Syndrome Scale (PANSS) and Nurses' Observation Scale for Inpatients Evaluation (NOSIE, for assessment of social function). For adjusting the within-subject dependence over repeated assessments, multiple linear regression with generalized estimating equation methods was utilized to analyse the effects of Ser311Cys polymorphism and other covariates on clinical performance. Compared with patients who had the Ser311Ser genotype, patients with the Ser311Cys genotype had lower scores on PANSS Positive, Negative, General Psychopathology and Cognitive subscales and NOSIE, after adjustment for 5-HT2A T102C polymorphisms and other confounders. The 5-HT2A T102C polymorphism had marginal influences on PANSS Total and Negative subscale scores. Male gender, fewer previous hospitalizations, and higher risperidone dose predicted better treatment response after control for other variables. The preliminary results suggest that variations in the DRD2 gene influence risperidone treatment response for positive, negative, and cognitive symptoms, general psychopathology, and social functioning. Several clinical factors may also contribute to inter-individual differences in risperidone treatment response.
關聯:	International Journal of Neuro-psychopharmacology 7(4), pp. 461-470
DOI:	10.1017/S1461145704004389
显示于类别:	[數學學系暨研究所] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
Effects of dopamine D2 receptor ser311 polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function.pdf		95Kb	Adobe PDF	1	检视/开启
index.html		0Kb	HTML	139	检视/开启

在機構典藏中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....