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Please use this identifier to cite or link to this item:
https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/58785
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Title: | Sarcosine (N-Methylglycine) Treatment for Acute Schizophrenia: A Randomized, Double-Blind Study |
Authors: | Lane, Hsien-Yuan;Liu, Yi-Ching;Huang, Chieh-Liang;Chang, Yue-Cune;Liau, Chun-Hui;Perng, Cheng-Hwang;Tsai, Guochuan E. |
Contributors: | 淡江大學數學學系 |
Keywords: | Glutamate;GlyT-1;N-methyl-D-aspartate;sarcosine;schizophrenia |
Date: | 2008-01 |
Issue Date: | 2011-10-01 21:11:01 (UTC+8) |
Publisher: | Philadelphia: Elsevier Inc. |
Abstract: | Background
Small molecules that enhance the N-methyl-D-aspartate (NMDA) neurotransmission have been shown to be beneficial as adjuvant therapy for schizophrenia. Among these compounds, sarcosine (a glycine transporter-I inhibitor), when added to an existing regimen of antipsychotic drugs, has shown its efficacy for both chronically stable and acutely ill patients. However, the efficacy of these agents as a primary antipsychotic agent has not yet been demonstrated.
Methods
Twenty acutely symptomatic drug-free patients with schizophrenia were randomly assigned under double-blind conditions to receive a 6-week trial of 2 g or 1 g of sarcosine daily.
Results
Overall, patients in the 2-g group were more likely to respond as defined by a 20% or more reduction of the Positive and Negative Syndrome Scale total score, particularly among antipsychotic-naïve patients. However, there was no significant between-group difference in the sarcosine dose × time interaction analysis. Both doses were well tolerated with minimal side effects.
Conclusions
Although patients receiving the 2-g daily dose were more likely to respond, it requires further clarification whether the effect is limited to the antipsychotic-naive population. Future placebo- or active-controlled, larger-sized studies are needed to fully assess sarcosine’s effects. |
Relation: | Biological Psychiatry 63(1), pp.9–12 |
DOI: | 10.1016/j.biopsych.2007.04.038 |
Appears in Collections: | [數學學系暨研究所] 期刊論文
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0006-3223_63(1)p9-12.pdf | | 84Kb | Adobe PDF | 351 | View/Open | index.html | | 0Kb | HTML | 110 | View/Open |
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