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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/58729

    Title: Epstein–Barr virus infection and plasma transforming growth factor-β1 levels in head and neck cancers
    Authors: Chen, Hong-wen;Yang, Sheau-fang;張玉坤;Cheng, Yue-cune;Wang, Tao-yeung;Chen, Yu-jen;Lai, Yuen-liang
    Contributors: 淡江大學數學學系
    Keywords: EBW;transforming growth factor-β1(TGf-β1;head and neck cancer;CCRT
    Date: 2008-10-01
    Issue Date: 2011-10-01 21:06:33 (UTC+8)
    Abstract: Conclusions. In addition to the correlation of transforming growth factor (TGF)-β1 levels to the radiation toxicity, both Epstein–Barr virus (EBV) infection and postoperative status play roles in the change in plasma TGF-β1 levels in patients with head and neck cancers. Objectives. To assess the parameters involved in the change in plasma TGF-β1 level during concurrent chemoradiotherapy (CCRT). Patients and methods. Blood samples (n=307) before, during, and after treatment were obtained from 39 patients with head and neck cancers treated with definitive or adjuvant CCRT. In situ hybridization (ISH) was used to identify EBV-encoded RNA (EBER) in tissues from the primary tumor or metastatic lymph nodes. Plasma TGF-β1 level, white blood cell (WBC), and platelet count were assayed immediately before the first fraction of radiotherapy (RT), once a week during RT, and at the end of the RT course. The grades of mucositis and dermatitis were recorded weekly during CCRT. Results. Pretreatment TGF-β1 level and radiation toxicity were found to be significantly correlated with the increase of the plasma TGF-β1 level during CCRT (p<0.05), but correlation of platelet count was only found in patients whose tumors were EBV-positive (p=0.0042), and WBC count in those treated with postoperative adjuvant CCRT (p=0.004).
    Relation: Acta Oto-Laryngologica 18, pp.1145-1151
    DOI: 10.1080/00016480701714293
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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