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    題名: In situ real-time investigation of cancer cell photothermolysis mediated by excited gold nanorod surface plasmons
    作者: Chen, Cheng-Lung;Kuo, Ling-Ru;Chang, Ching-Lin;Hwu, Yeu-Kuang;Huang, Cheng-Kuang;Lee, Shin-Yu;Chen, Kowa;Lin, Su-Jien;Huamg, Jing-Duan;Chen, Yang-Yuan
    貢獻者: 淡江大學物理學系
    關鍵詞: Gold;Plasma;Membrane;Laser;Fluorescence
    日期: 2010-05
    上傳時間: 2011-09-30 22:01:20 (UTC+8)
    出版者: Amsterdam: Elsevier BV
    摘要: The photothermolysis of living EMT-6 breast tumor cells triggered by gold nanorods (AuNRs) with two-photon irradiation was conducted in situ and under real-time observation. The morphology and plasma membrane permeability of the cells were key indicators to the phenomena. AuNRs with an aspect ratio of 3.92, and a longitudinal absorption peak at 800 nm were synthesized with a seed-mediated method. The nanorods surfaces were further modified with polystyrenesulfonate (PSS) for biocompatibility. The prepared nanorods displayed excellent two-photon photoluminescence imaging. In situ real-time results revealed cavities internal to the cells were created from thermal explosions triggered by AuNRs localized photothermal effect. The cavitation dynamic is energy dependent and responsible for the perforation or sudden rupture of the plasma membrane. The energy threshold for cell therapy depended significantly on the number of nanorods taken up per cell. For an ingested AuNR cluster quantity N ∼ 10–30 per cell, it is found that energy fluences E larger-than 93 mJ/cm2 led to effective cell destruction in the crumbled form within a very short period. As for a lower energy level E = 18 mJ/cm2 with N ∼ 60–100, a non-instant, but progressive cell deterioration, is observed.
    關聯: Biomaterials 31(14), pp.4104–4112
    DOI: 10.1016/j.biomaterials.2010.01.140
    顯示於類別:[物理學系暨研究所] 期刊論文

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