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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/58018


    Title: Preparation of environmental-responsive chitosan-based nanoparticles by self-assembly method
    Authors: Chuang, Chung-Yang;Don, Trong-Min;Chiu, Wen-Ye
    Contributors: 淡江大學化學工程與材料工程學系
    Keywords: Chitosan;N-isopropylacrylamide;Nanoparticles;Self-assembly;Thermo–pH response
    Date: 2011-03
    Issue Date: 2011-09-28 11:52:59 (UTC+8)
    Publisher: Kidlington: Pergamon
    Abstract: In this research, environmental-responsive nanoparticles of chitosan-graft-poly(N-isopropylacrylamide) copolymers (CS-g-PNIPAAm) were prepared by the self-assembly method. The copolymer was first synthesized through polymerization of NIPAAm monomer in the presence of CS in an aqueous solution using cerium ammonium nitrate as the initiator. Then, the CS-g-PNIPAAm solution was diluted by deionized water and heated to a proper temperature for CS-g-PNIPAAm to undergo self-assembly. Micelles of CS-g-PNIPAAm were formed, and glutaraldehyde was added to reinforce the micelle structure to form nanoparticles. TEM images showed that a porous or hollow structure of nanoparticles was developed. The synthesized nanoparticles carried positive charges on the surface and their mean diameter could be manipulated by changing the temperature of environment. These nanoparticles with environmentally sensitive properties are expected to be utilized in hydrophilic drug delivery system.
    Relation: Carbohydrate Polymers 84(2), pp.765-769
    DOI: 10.1016/j.carbpol.2010.01.053
    Appears in Collections:[化學工程與材料工程學系暨研究所] 期刊論文

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