| 摘要: | 超分子化學可視為分子之後的化學,這個研究已然是一個跨領域的科學研究最重要的課題之一.基於我們研究群已經開發出的.基多比定型螺旋超分子體系,將以此為基礎進行本研究計劃.本計劃中以超分子的分子級科學之基礎研究開發,進而於新穎材料及生物科技領域之應用. 基礎科學研究中包括了合成新穎超分子百餘個,鑑定其結構及基本光譜學性質,物理性質及化學性質,探討其電化學性質,氧化還原性質,熱力學性質,光物理及光化學性質,自我組裝程序,晶體工學性質,以及上述性質之量子力學理論計算研究. 奈米材料的應用研究中包括了新穎液晶材料,奈米金屬導線,奈米金屬顆粒,有機導電材料,單分子自組薄膜,分子電子元件,化學感測器,分子導線以及表面化學之研究. 螺旋超分子在生物化學的應用研究中包括了此類分子與 DNA 蛋白質的結合研究,抗癌藥物的研究開發,蛋白質學的研究,以及生物感測器的研究. Supramolecular chemistry is currently defined as the chemistry beyond the molecule, comprising the design and studies of intermolecularly bonded chemical species. This emergent and interdisciplinary field science has seen a rapid growth in recent years, as attested by the fertility of the research made and the offered perspectives. In artificial supramolecular architectures, helicity can be introduced by conformational restrictions of macromolecules, inter- or intramolecular hydrogen bonds, or coordination to metal ions. Based on our preliminary results of hydrazone linking helical polypyridyl coordination complexes, the main core compound of this proposal is helical Supramolecules. The proposal will be addressed on the development of these helical Supramolecules in nano-science from the basic research to new materials and biological field applications. The basic research will be involved in the synthesis and characterization, structural and spectroscopic properties, the study of the photophysics and photochemistry, electrochemical properties, thermal and thermodynamic properties, theoretical calculation, self-assembly process, and crystal engineering to conduct the molecular level information. The material research will be focus on the development of helical-typed liquid crystal, nano-metal wire, molecular wire, nano-metal particle, molecular device, organic conductive material, self-assembly monolayer, and Supramolecules in the surface array. The biological application is try to use the unique properties of these helical Supramolecules to examine their affinity toward biomolecules and biopolymers, the anticancer activity, the new tools for the proteomic research, bio- and chemical sensor, and the materials for solving the problems in biochips. |
