Condensed multilamellar structure of a complex of DNA with an amphiphilic block copolymer

doi:10.1039/b715045h

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Title:	Condensed multilamellar structure of a complex of DNA with an amphiphilic block copolymer
Authors:	Su, Chun-jen;Yeh, Sheng-wei;Lai, Wei-chi;Chen, Hsin-lung;M. Habibur Rahman;Wu, Ren-jye;Lin, Hsien-kuang;Liu, Wen-liang
Contributors:	淡江大學化學工程與材料工程學系
Date:	2008-06
Issue Date:	2011-05-20 09:56:57 (UTC+8)
Publisher:	RSC Publishing
Abstract:	Deoxyribonucleic acid (DNA) is an attractive building block for self-assembled nanostructures, because the anionic phosphate group and the base moiety allow it to bind with a broad spectrum of organic and inorganic species through ionic and hydrogen bonding. Here we present a hierarchical structure formed by the ionic complex of DNA with an amphiphilic block copolymer comprising a cationic block. Upon the complexation the cationic block chains wrap around DNA for charge matching and the microphase separation between the hydrophobic block and the hydrophilic component yields a multilamellar structure with liquid crystalline ordering of the DNA chains condensed in the hydrophilic microdomains. Each hydrophilic lamellar domain is found to contain two DNA sublayers separated by a thin water gap, with each sublayer comprising two rows of densely packed DNA chains to lower the interfacial free energy for the present system with strong polar–nonpolar repulsion.
Relation:	Soft Matter 4(6), pp.1306-1312
DOI:	10.1039/b715045h
Appears in Collections:	[Graduate Institute & Department of Chemical and Materials Engineering] Journal Article

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